Good Morning. Moderna and Merck said their custom-built cancer vaccine stopped melanoma from returning in 1,137 patients. Plus, a 4% treasury return, Prime’s drone expansion and Target’s turnaround (forwarded this email? Join 523k readers).
Our most clicked link yesterday: He made billions working 2/hours per day
TOP STORY TODAY
Cancer Vaccine
A personalized mRNA vaccine kept skin cancer from coming back or spreading in a trial of 1,137 melanoma patients, Moderna and Merck said yesterday. It is the first mRNA cancer therapy to clear late-stage testing.
Every dose is built for one person. An algorithm compares the patient's sequenced tumor against healthy cells, picks up to 34 mutated proteins, and encodes those into a shot no one else can use.
Moderna closed up 177% Wednesday, lifting its market value from roughly $25 billion to $69 billion. Merck rose about 13%. Full data is unpublished, and neither company has filed for approval yet. The trial readout Merck published
$40 Trillion in Debt
Total US government debt topped $40 trillion for the first time, the Treasury Department said Wednesday. The figure hit $40.05 trillion Tuesday, four and a half years after crossing $30 trillion.
That works out to about $117,000 per person and $297,000 per household. Interest alone has cost nearly $1.2 trillion this fiscal year, more than every federal program except Social Security and Medicare.
Bond investors are now charging more to lend. The 30-year Treasury yield touched 5.32% this week, its highest since 2007, and Treasury interest is exempt from state and local income tax. How this happens.
Urine For Data Centers?
Liquid Death and Garage Beer released a 90-second music video Tuesday asking Americans to mail their urine to AI data centers. Jason Kelce, who co-owns Garage Beer with brother Travis, stars (Video).
It opens with Kelce filling a mason jar over a toilet. A crowd later hauls jars to a post office while an onscreen disclaimer asks viewers not to actually send anything (in reality, urine would destroy the servers).
Large facilities can draw up to 5 million gallons of water daily for cooling. Seven in ten Americans oppose a data center in their area, more than oppose a local nuclear plant. How data centers change your electric bill.
TOGETHER WITH SHIPSTATION
The business was supposed to give you more time, not less
Nobody starts a business to spend Sunday night copying addresses between tabs. But that is where a lot of owners end up once orders come from three or four places at once and every one of them wants to be handled by hand.
ShipStation centralizes those orders into one dashboard, sets rules that pick the carrier and service for you, and prints in batches instead of one at a time. Tracking updates send themselves.
The work still gets done. It just stops eating the part of your week that belongs to your family.
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GET 1% BETTER
10 things you should be spending more money on
Codie Sanchez says the hard part isn't making money, it's knowing what to do with it. So she runs one number first. Take your net income, divide by roughly 2,000 working hours, then cut that in half. At $100k a year, your hour is worth $50 and your buyback rate is $25. Anything you can hand off for less than that, you hand off.
One expensive thing you wear constantly
Proximity: shorter commute, better gym, a room with owners
Appearance upkeep, starting with a cheap red light
A tax advisor, not a financial advisor
An exit fund for breaking leases and contracts
Real food, or a meal service if the math clears
An assistant, from $200 a month
Sleep: hard mattress, earplugs, face mask
Skills you'll repeat a thousand times, like negotiation
Your time, unapologetically
Her line is the one that stings: "It's faster if I just do it" is why most people stay stuck. You're faster once. Not the fifty-first time. Watch her breakdown.
Bank rate we're fact-checking
The FDIC says the average American savings account pays 0.38%. A six-month Treasury bill right now pays close to 4%. On $20,000, that is the difference between earning about $76 this year and earning about $850. The Finance Bureau explains why almost nobody has noticed.
For eighteen years, cash lost to inflation on purpose. The Fed pinned rates near zero, safe money was a guaranteed way to get poorer, and an entire generation of savers stopped checking because there was nothing worth moving to. That is no longer true. The 10-year real yield is the highest since October 2008.
Your bank has no reason to mention this. Look up what your account actually pays, then go see what a bill pays.
TRENDING
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▲ Drone delivery costs Prime members nothing over $50, $2.99 under, $4.99 without a membership | Every city on the list
▲ Target banked $994 million in tariff refunds, part of $166 billion owed to 330,000 importers | Prices cut on 10,000 items
▲ Heartbeat-powered pacemaker could end the repeat surgeries younger patients now face every seven to ten years | The team and the paper
▲ Canada tariffs paused until Friday, hours before 50% duties hit $28 billion in goods | The 1930 law behind it
▲ AI hiring worries 85% of Americans, ranking above self-driving cars and AI medical advice | Trust fell again this year
TOGETHER WITH CAKES
She has tried every version of this and stopped looking
Boob tape pulls. Bras are uncomfortable. Covers that promise lift either flatten the shape or give out halfway through dinner. Most women land on picking the least annoying option and living with it.
CAKES Lift is the fix for all three complaints at once. Longer tabs for real hold, wider coverage for a rounded shape rather than a flat one, and gentle silicone that feels like nothing. Dermatologist-tested and kind to skin.
It goes on in four steps, adjusts to the neckline, and lasts five or more wears. Sizes for A through DD in Honey, Caramel, and Cocoa.
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